Search on: NOVO SUNDAC 
Descriptors Found: 1
Displaying: 1 .. 1  

 1 / 1 DeCS     
Descriptor English:   Sulindac 
Descriptor Spanish:   Sulindac 
Descriptor Portuguese:   Sulindaco 
Synonyms English:   Aclin
Apo-Sulin
Arthrobid
Arthrocine
Chibret
Clinoril
Copal
Kenalin
Klinoril
MK-231
Novo-Sundac
Nu-Sulindac
Sulindal
Apo Sulin
MK 231
MK231
Novo Sundac
Nu Sulindac  
Tree Number:   D02.455.426.559.847.486.875
D04.615.486.875
Definition English:   A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects. 
Pharmacological Action:   Anti-Inflammatory Agents, Non-Steroidal
Antineoplastic Agents
Cyclooxygenase Inhibitors
 
History Note English:   90(79); was see under INDENES 1979-89 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   27862 
Unique Identifier:   D013467 

Occurrence in VHL:
 

Similar:

 
DeCS CID-10 SciELO LILACS LIS